![]() The result of Hartwig and Siegel scale, most ADRs of platinum analogs showed "moderate" followed by "mild" and "severe". Assessment with Naranjo's Algorithm and WHO assessment scale indicated most ADRs are "possible" than "probable". The major adverse drug reactions included vomiting (35.49%) followed by alopecia (22.95 %), nausea (19.4%), anorexia, diarrhea, taste alteration, constipation, tinnitus, abnormal renal, and dizziness. ![]() Hence, a systematic review was discussed by identified and analyzed 3 relevant studies. Animal studies and case reports were excluded. ![]() The inclusion criteria were as follow original articles that reported platinum effects in humans, articles that discuss the effects of platinum, articles that assessed causality or severity or preventability of platinum agents, and articles published in the last ten years. A bibliographic search was performed in the following databases: PubMed, ScienceDirect, and Google Scholar, search covering the period 2010 to 2020. The objective of this study was to summarize recent evidence obtained from Adverse Drug Reactions (ADRs) of platinum analogs and to know what are exactly the most common ADRs in platinum, their frequency, causality, severity, and preventability. ![]()
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